An introduction to the principles of tissue engineering: interplay and design of cells, biomaterials, and bioactive molecules to assist the body in the repair of damaged tissues. This includes concepts such as examining material fabrication approaches, engineering cells and their behavior, studying tissue microenvironments from diverse organ systems, the role of the extracellular matrix in repair, in vitro approaches to tissue engineering, and delivery of bioactive molecules (growth factors, extracellular vesicles, etc.), among others. By the end of this course, students will be able to design and evaluate tissue engineered constructs to repair a specific organ system.