Displaying 1 - 46 of 46
Course Units Instructor Prerequisites Description
201A Protein Structure & Function 2

Graduate standing.

Exploration of the relationship between protein sequence, structure, biophysics, and function.

201B Chemistry & Structure of Nucleic Acids 2

One year of undergraduate biochemistry (e.g., MCDB 108A-B-C), one quarter of undergraduate physical chemistry (e.g., Chemistry and Biochemistry 142A-B-C, Chemistry and Biochemistry 113A).

Primary, secondary, and higher-order structures of DNA and RNA, thermodynamic stability and folding, protein-nucleic acid interactions, ribozymes, applications to gene regulation, RNA world evolution.

201C Biomembranes Structure & Function 2

Chemistry and Biochemistry 142A-B-C or MCDB 108A-B-C or equivalents.

Lipid diversity, lipid aggregates, dynamics and phase behavior of lipid aggregates, permeabilities of model and cellular bilayers, manipulation and quantitation of ionic and pH gradients, related special topics in physiology such as the mechanisms of anesthesia.

202 Biomaterials &. Biosurfaces 3

Consent of instructor. Same course as Chemical Engineering 202. Recommended preparation: prior biochemistry, physical chemistry, and organic chemistry.

Fundamentals of natural and artificial biomaterials and biosurfaces with emphasis on molecular level structure and function and the interactions of biomaterials and surfaces with the body. Design issues of grafts and biopolymers. Basic biological and biochemical systems reviewed for nonbiologists.

204 Protein Processing 4

MCDB 108A or 218A or equivalent.

Structure/function relationships in interesting macromolecules isolated from marine organisms. Focus is on well-characterized pathways from horseshoe crabs, abalones, mussels, and fish as well as others.

205A Biochemical Kinetics 1

One year of undergraduate biochemistry (e.g., MCDB 108A-B-C) or equivalent.

A practical approach to purifying and working with proteins in the laboratory. Emphasis is on techniques (mainly qualitative) with a focus on modern methods used in the research literature. Students will have an intuitive sense of protein purification, manipulations, and analysis, and should be able to critically read the primary literature upon

205B Strategies in Protein Chararacterization 1

A grade of B- or better in MCDB 108A or 208A or the equivalent.

A presentation of traditional and state-of-the-art approaches for characterizing the primary structure of proteins and polysaccharides. Techniques include amino acid analysis, mass spectroscopy, gas-phase sequencing, capillary electrophoresis, and covalent modification chemistry.

207 Enzyme Mechanisms 2

Undergraduate biochemistry course (e.g., MCDB 108).

Chemical mechanisms of enzyme catalysis. Enzyme models and non-classical enzymes. Theory, experimental design, and data analysis.

215 Biophysical Thermodynynamics 2

Undergraduate course in physical chemistry (e.g., Chemistry and Biochemistry 113A-B-C).

An overview of those parts of chemical thermodynamics relevant to the study of biomolecules and biological systems. Topics include fundamental thermodynamics, experimental and theoretical tools and the thermodynamics of biopolymer structure formation.

217 Electrostatics of Biopolymers 2

Knowledge of elementary ideas and methods of electrostatics and statistical mechanics.

Knowledge of elementary ideas and methods of electrostatics and statistical mechanics.

220A Chromosomes & Cell Cycle 2

Graduate standing.

Structure and organization of the nucleus, Chromatin and chromosome structure, organization, and function; DNA replication and replication origins; Eukaryotic cell cycle regulation.

220B Cytoskeleton 2

Graduate standing

Structure and function of the eucaryotic cytoskeleton. Structure assembly and function of microtubules, microfilaments, and intermediate filaments.

220C From RNA to Membranes 2

Undergraduate biochemistry (e.g., MCDB 108A-B-C or Chemistry and Biochemistry 142A-B-C) and genetics (e.g., MCDB 101A).

Structure and dynamics of biological membranes and membrane proteins, protein translocation and sorting in the endomembrane system of eukaryotic cells, extracellular matrix protein structure / function, cell-matrix and cell-cell interactions, cell adhesion receptors, transmembrane signaling by cell adhesion receptors.

222A Colloids & Interfaces I 3

Consent of instructor.

Introduction to the various intermolecular interactions in solution and in colloidal systems: Van der Waals, electrostatic, hydrophobic, solvation, H-bonding. Introduction to colloidal systems: particles, micelles, polymers, etc. Surfaces: wetting, contact angles, surface tensions, etc.

222B Colloids and Interfaces II 3

Consent of instructor. Recommended Preparation: Materials 222A or Chemical Engineering 222A or BMSE 222A. Materials 222A or Chemical Engineering 222A recommended. Same course as Materials 222B or Chemical Engineering 222B.

Continuation of 222A. Interparticle interactions, coagulation, DLVO theory, steric interactions, polymer- coated surfaces, polymers in solution, thin film viscosity. Surfactant and lipid self-assembly: micelles,microemulsions. Surfactants on surfaces: langmuir- blodgett films, adsorption, adhesion, friction. Biomolecular self-assembly, biological systems.

223 Signal Transduction 2

Graduate standing.

A cell's growth is controlled by positive and negative cues from its surroundings. A discussion of the cell's signaling mechanisms that recognize these cues and initiate an intracellular set of events that generates a response.

229 Protein Biochemistry 2

Graduate standing.

Discussion topics relevant to structure-function relationships in proteins including the chemical reactivity of amino acid side chains, posttranslational modifications, and the covalent and noncovalent interactions of multimeric structures. Case studies involve recent advances in structure-function relationships of mechanoproteins.

230 Gene Regulation 2

Graduate standing.

Mechanisms and regulation of transcription and translation in prokaryotic and eukaryotic organisms and their viruses.

232 Bacterial Pathogenesis 3

The mechanisms by which bacterial pathogens cause disease. Investigation of the bacterial gene products produced during infection to understand the metabolic, physiological, and genetic factors that contribute to the virulence of bacterial pathogens.

232L Bacterial Pathogenesis Lab 3

The latest molecular, biochemical, and genetic techniques available for the identification of microbial gene products that contribute to infection.Study of the regulatory parameters that govern their expression.

233 Cell Biology 4

Same as MCDB 203, Consent of Instructor.

Introduction to the structure and function of cell organelles: membranes, nucleus, mitochondria, chloroplasts, endoplasmic reticulum, golgi apparatus, lysosomes, microbodies, microtubules, cilia, centrioles, and microfilaments.

235 Experimental Strategies in Molecular Genetics 1

Undergraduate biochemistry (e.g., MCDB 108A-B-C) and genetics (e.g., MCDB 101A-B-C).

Discussion of experimental strategies used to purify, analyze, and manipulate nucleic acids, isolate molecular clones from complex genomes, physically map genomes, analyze gene expression, and perform reverse genetics.

244 Informational Macro- and Supra-Molecules 2

Consent of instructor. Same course as Chemistry 244.

Selected topics at the interface of chemistry and biology: informational molecular coding, molecular machines, self-assembling and self-replicating molecular systems, evolution and selection of molecules with binding of catalytic properties, and biopolymer based materials; special emphasis on cutting-edge technologie.

246 Membrane Biochem 4

Chemistry and Biochemistry 142A-B-C. Same course as Chemistry and Biochemistry 246.

Introduction to the structures and roles of lipids and their behavior, lipsomes, membrane proteins and kinetics, protein sorting, and signal transduction.

247 Quantitative Methods in Biology 3

One year of calculus or consent of instructor.

A review of quantitative methods required to develop models of biological and ecological systems. Topics illustrated through computer exercises.

250 Bionanotechnology 2

Background in biochemistry and molecular biology.

Introduction to macromolecular assemblies and force generation strategies. Topics may also include but are not limited to: conformations and behavior of protein polymers; nucleic acid superstructures and membranes; structure, motility and mechanism of linear and rotary motor proteins; and macromolecular switches.

251 Biopharm Process Engineering 2

Mathematics 5A or equivalent; background in biochemistry.

An introduction to the design bioprocess for large-scale production of biopharmaceuticals. Emphasis is placed upon biopharmaceutical products, protein expression systems, host cell optimization, and reactor selection and design.

252 Principles Bioengineering 2

An overview of various aspects of bioengineering including modeling of physiological functions, biomedical devices, drug delivery, and tissue engineering.

253 Analytical Biotechnology 3

Graduate standing. Effective Date changed to S05 per Grad Div (5/3/05). ME 291A.

Develops fundamental understanding behind modern methods of biotechnology. Topics include theoretical treatment of the double layer, electrophoresis, polymerase chain reaction, modern optics, and fluorescence. In addition, case studies of contemporary emerging trends are discussed.

254 Drug Design 3

Chemistry 142A-B-C or Biology 108A-B-C.

Rational and structure-based drug design; pharmacogenetics; combinatorial chemistry and screens; mechanism-based drug design; drug metabolism; toxicity; quantitative structure activity relationships; enzyme inhibitors.

255 Systems Biology 3

Prior course work in cellular biology, mathematics; consent of instuctor.

Fundamentals of dynamic network organization in biology (genes, metabolites). Emphasis on mathematical approaches to model and analyze complex biophysical network systems. Detailed case studies demonstrating successes of systems biology. Basic biological systems reviewed for nonbiologists.

257 Special Topics in Bio Physics 1 to 4

May be repeated for credit provided topics are different.

Course varies from year to year according to the currents of the times.

259 Special Topics Biochemistry 1 to 4

Consent of instructor.

Selected topics from bio-organic, biophysical, or biological chemistry. The content of this course will vary.

262 BMSE Research Progress in BMSE 1

Research presentations by advanced Ph.D. students on research progress in BMSE & MCDB.

264 Literature in Signal Transduction 1

Graduate standing.

Critical reading and presentation of the literature on signal transduction mechanisms t

265 BMSE Sem Discussion Group 1

None; intended for non-advanced BMSE graduate students only.

A weekly seminar discussion group to review, in advance, relevant literature of participating BMSE seminar guests.

272 Mechanical Force and Biomolecules 3

Explores single-molecule biophysics and the role of mechanical force in biomolecular behavior. Emphasis is placed on modern experimental techniques and the effects of mechanical stress on DNA conformation, protein unfolding, and force-generation by motor proteins. Recent literature is used throughout.

276A Biomolecular Materials I: Structure and Function 3

Consent of instructor. Concurrently offered with Mat 276A.

Survey of classes of biomolecules (lipids, carbohydrates, proteins, nucleic acids). Structure and function of molecular machines (enzymes for biosynthesis, motors, pumps).

276B Biomolecular Materials II 3

Consent of instructor.

Selected topics from bio-organic, biophysical, or biological chemistry. Thecontent of this course will vary.

290XX Group Studies 2

Consent of Instructor.

Presentation and discussion of current research, to be selected from the following list: A. Biomolecular Materials Synthesis; B. Biomineralization; BP. Bacterial Pathogenesis; CE. C. elegans Development; DN. Developmental Neurobiology; HW. Marine Structural Proteins; PM. Molecular Plant-Microbe Interactions; PR. Protein-Nucleic Acid Interactions; S. Molecular Virology and Interferon Action.

293 Computational Methods Biochemistry & Molecular Biology 1

Graduate standing.

Survey of computational methods in molecular biology. Topics include analysis and presentation of data, database searching, quantitative image analysis, and protein homology modeling. Emphaisis is on utilizing accessible software tools that are designed for non-programmers.

592 BMSE Lab Rotation 4

Enrollment in the BMSE Ph.D. program; open to first year graduate students only.

Laboratory rotation project in BMSE faculty laboratories.

595 Biochemistry & Molecular Biology Literature Seminar 2

Consent of instructor; graduate standing.

A critical review of research in selected areas of biochemistry-molecular biology.

595XX Critical Review of Selected Literature 2

Consent of instructor.

A critical review of literature in specified research areas.

596 Directed Reading Research 2 to 12

Graduate standing; consent of instructor.

Individual tutorial. Instructor is usually the student's major research advisor. Each faculty member has a unique number designation.

599 PhD Dissert preparation 3 to 12

Graduate standing as a Ph.D. student and advancement to Doctoral Candidacy.

Writing of the Ph.D. dissertation.