Lipid diversity, lipid aggregates, dynamics and phase behavior of lipid aggregates, permeabilities of model and cellular bilayers, manipulation and quantitation of ionic and pH gradients, related special topics in physiology such as the mechanisms of anesthesia.

Structure/function relationships in interesting macromolecules isolated from marine organisms. Focus is on well-characterized pathways from horseshoe crabs, abalones, mussels, and fish as well as others.

A presentation of traditional and state-of-the-art approaches for characterizing the primary structure of proteins and polysaccharides. Techniques include amino acid analysis, mass spectroscopy, gas-phase sequencing, capillary electrophoresis, and covalent modification chemistry.

An overview of those parts of chemical thermodynamics relevant to the study of biomolecules and biological systems. Topics include fundamental thermodynamics, experimental and theoretical tools and the thermodynamics of biopolymer structure formation.

Structure and organization of the nucleus, Chromatin and chromosome structure, organization, and function; DNA replication and replication origins; Eukaryotic cell cycle regulation.

Structure and dynamics of biological membranes and membrane proteins, protein translocation and sorting in the endomembrane system of eukaryotic cells, extracellular matrix protein structure / function, cell-matrix and cell-cell interactions, cell adhesion receptors, transmembrane signaling by cell adhesion receptors.

Continuation of 222A. Interparticle interactions, coagulation, DLVO theory, steric interactions, polymer- coated surfaces, polymers in solution, thin film viscosity. Surfactant and lipid self-assembly: micelles,microemulsions. Surfactants on surfaces: langmuir- blodgett films, adsorption, adhesion, friction. Biomolecular self-assembly, biological systems.

Discussion topics relevant to structure-function relationships in proteins including the chemical reactivity of amino acid side chains, posttranslational modifications, and the covalent and noncovalent interactions of multimeric structures. Case studies involve recent advances in structure-function relationships of mechanoproteins.

The mechanisms by which bacterial pathogens cause disease. Investigation of the bacterial gene products produced during infection to understand the metabolic, physiological, and genetic factors that contribute to the virulence of bacterial pathogens.

Introduction to the structure and function of cell organelles: membranes, nucleus, mitochondria, chloroplasts, endoplasmic reticulum, golgi apparatus, lysosomes, microbodies, microtubules, cilia, centrioles, and microfilaments.

Selected topics at the interface of chemistry and biology: informational molecular coding, molecular machines, self-assembling and self-replicating molecular systems, evolution and selection of molecules with binding of catalytic properties, and biopolymer based materials; special emphasis on cutting-edge technologie.

A review of quantitative methods required to develop models of biological and ecological systems. Topics illustrated through computer exercises.

An introduction to the design bioprocess for large-scale production of biopharmaceuticals. Emphasis is placed upon biopharmaceutical products, protein expression systems, host cell optimization, and reactor selection and design.

Develops fundamental understanding behind modern methods of biotechnology. Topics include theoretical treatment of the double layer, electrophoresis, polymerase chain reaction, modern optics, and fluorescence. In addition, case studies of contemporary emerging trends are discussed.

Fundamentals of dynamic network organization in biology (genes, metabolites). Emphasis on mathematical approaches to model and analyze complex biophysical network systems. Detailed case studies demonstrating successes of systems biology. Basic biological systems reviewed for nonbiologists.

Selected topics from bio-organic, biophysical, or biological chemistry. The content of this course will vary.

Critical reading and presentation of the literature on signal transduction mechanisms t

Explores single-molecule biophysics and the role of mechanical force in biomolecular behavior. Emphasis is placed on modern experimental techniques and the effects of mechanical stress on DNA conformation, protein unfolding, and force-generation by motor proteins. Recent literature is used throughout.

Selected topics from bio-organic, biophysical, or biological chemistry. Thecontent of this course will vary.

Survey of computational methods in molecular biology. Topics include analysis and presentation of data, database searching, quantitative image analysis, and protein homology modeling. Emphaisis is on utilizing accessible software tools that are designed for non-programmers.

A critical review of research in selected areas of biochemistry-molecular biology.

Individual tutorial. Instructor is usually the student's major research advisor. Each faculty member has a unique number designation.