Physicists at UC Santa Barbara have created a microscopic device to assist biologists in making very fast molecular measurements that aid the understanding of protein folding. This development may help elucidate biological processes associated with diseases such as Alzheimer's and Parkinson's. Since proteins in the body perform different functions according to their shape, the folding process is considered a key area of study.
Using a microfabricated fluid mixing device built at UCSB's nanofabrication facility, UCSB physicists and their collaborators from the University of Zurich have made the first sub-second, single-molecule measurements of an essential biological molecule known as a chaperonin. The results are published in this week's online issue of the Proceedings of the National Academy of Sciences.