Systems biology focuses on the study of the interactions between the components of a biological system, and how these interactions give rise to the function and behavior of that system. Our research considers a number of different aspects of systems biology such as the application of dynamical systems theory to biological systems, extraction, representation, integration and analysis of data from multiple experimental sources, and reconstruction of dynamic systems from the quantitative properties of their building blocks.
Theoretical ecology, disease ecology, population dynamics, and systems biology.
The origin of life; principles of biomolecular function and design; evolutionary systems biology; phage therapy.
Biochemistry; protein structure and function relationships; protein dynamics; chemotaxis in bacteria.
Basic mechanisms and disorders of neural plasticity; the role of microRNAs in stem cell differentiation.
Cellular communication between bacteria, including mechanisms and biology of contact-dependent growth inhibition; epigenetic gene regulatory mechanisms.
Microbial pathogenesis; innate and adaptive immune responses to infection; coagulopathy and inflammation of sepsis; vaccine development.
Nanomedicine and bioengineering to explore fundamental biology, construct new approaches to disease diagnosis, and develop effective means for disease prevention, therapy, and cure.
Biological regulatory networks in C. elegans development; mechanisms of apoptosis and tumorigenesis; regulatory mechanisms in stem cell biology.
Quantitative systems biology and bioinformatics; statistical mechanics of non-equilibrium systems.
Analysis of biological data including sequences, structures, and images; synthesis and analysis of biological networks.
Design, synthesis, and characterization of new bioinorganic materials with an emphasis on understanding interface assembly & control of bioprocesses.